Téma: Overview works

Current view on immunopathogenesis of coeliac disease

Milan Buc

Coeliac disease (CD) is an autoimmune disorder of the small intestine that results from the immune response to various cereal proteins, mostly gliadin. It is a genetically determined disease; among predisposing genes those of the HLA complex are of paramount importance, especially the alleles coding for HLA-DQ2 (90-95 % of CD patients) and HLA–DQ8 (3 - 5 % of CD patients) molecules, respectively. They present a peptide originating from gliadin to autoreactive T-cell. However, before they are able to do it, gliadin has to be deaminated by a tissue transglutaminase 2. TH1- cell mediated immune response is responsible for immunopathological changes, which are very efficiently supported by IgA anti - TG2 autoantibodies. The formed immunocomplexes are deposited into subepithelial layer of the intestine. As polymeric forms of IgA are able to activate the lectine pathway of the complement system, is it activated and contributes to inflammatory processes. Some patients also produce autoantibodies against epidermal transglataminase what can result into the development of dermatitis herpertiformis.

Ročník 2004  Témy časopisu Internal medicine 6 / 2004

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prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
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MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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c. propionibacterium acnes
d. endothelial growth factor


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