Téma: Overview works

Tuberculosis and symptoms similar to sle as a complication of biological anti-tnf therapy

Milan Buc, Jozef Rovenský

Autoimmunity disorders represent mutually intertwined reactions of both innate and adaptive immune responses. It was shown that the tumor necrosis factor (TNF) is of paramount importance in immunopathological processes in some autoimmune diseases. Biological substances were therefore developed with the aim to neutralize it. Chimeric anti-TNF monoclonal antibodies (infliximab), totaly humanized anti-TNF monoclonal antibodies (adalimumab) and soluble IgG1 fusion TNF binding protein (etanercept) were approved for the treatment of rheumatoid arthritis and M. Crohn. Their use in the clinical practice has been of great benefit for patients; both monoclonal antibodies and TNF-binding receptors are effective in the treatment of both rheumatoid arthritis and M. Crohn, contrary to monoclonal antibodies in the treatment of M. Crohn only. However, interfering with functions of the immune system can cause some serious complications, esp. the reactivation of the tuberculosis process, esp. when monoclonal antibodies are applied and the induction of systemic lupus erythematosus.

Ročník 2004  Témy časopisu Internal medicine 7 / 2004

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MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
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prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
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prof. MUDr. Juraj Payer, CSc., FRCP
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prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
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2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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