Téma: Overview works

Risk profile and anticipated benefit of pharmacological treatment in patients with newly diagnosed type 2 diabetes

Ivan Tkáč, Lucia Baldaufová

The patients with type 2 diabetes have an increased risk of cardiovascular disease even in the time when the diagnosis of diabetes is established. We have analysed atherosclerosis risk factor profile in a group of 1471 newly diagnosed patients with type 2 diabetes. Mean glycated haemoglobin (GHb) at the time of diagnosis was 8,4 %, mean LDL cholesterol level was 3,4 mmol/l, and mean blood pressure was 140/84 mmHg. At the time of diagnosis of diabetes 74 % of diabetic patients had GHb level >7,5 %, 87 % of patients had LDL cholesterol level > 2,5 mmol/l, and 64 % of diabetic patients had systolic blood pressure above 130 mmHg. Using the UKPDS Risk Engine calculated 10-year absolute risk of coronary heart disease in men with newly diagnosed type 2 diabetes is 23,1 %, while in women it is 14,4 %. If target GHb, LDL cholesterol and systolic blood pressure values were achieved, then calculated risk of coronary disease in both genders would decrease by more than 40 % and the risk of fatal cardiovascular disease would be reduced by one half. These facts indicate high risk of patients with newly diagnosed type 2 diabetes and show also high preventive potential of treatments focused on high blood glucose, cholesterol and blood pressure levels.

Ročník 2005  Témy časopisu Internal medicine 9 / 2005

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prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
prof. MUDr. Juraj Payer, CSc., FRCP

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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d. endothelial growth factor


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