Anna Remková
Thromboembolic complications are among the most important causes of maternal mortality. In a history of recurrent thromboembolic episodes or in acute venous thromboembolism antepartum adjusted - dose heparin is recommended. In patients with a history of single thromboembolic episode and thrombophilia or family history of thrombosis, antepartum prophylactic minidose or moderate-dose heparin is suggested. Heparins seem to have a positive effect on pregnancy outcome after spontaneous abortions. For pregnant patients with antiphospholipid antibodies and a history of pregnancy losses, aspirin plus prophylactic dose of heparin is usually administrated. Data on pregnancy complications in women with heritable thrombophilia or a history of thrombosis are inconsistent. Treatment with heparin might be considered in those women with pregnancy loss and inherited thrombophilia. Further randomized trials are urgently needed.