Téma: Clinical pharmacology

New basal insulin analogue - insulin detemir

Zbynek Schroner

Onset and duration of action of basal insulin analogues reproduce more accurately the physiological, pulsatile basal insulin secretion. Basal analogue-insulin glargin has been used in Slovakia for some years and now new basal insulin analogue – insulin detemir is coming into routine clinical practice. Duration of action of insulin detemir is up to 24 hours and is administered once or twice daily in dependence of dose. Recently done trials have shown that its administration is associated with lower risk of hypoglycaemia, mainly nocturnal, in comparison with insulin NPH. Treatment with insulin detemir was associated with reduction of body weight in patients with type 1 diabetes mellitus as well with significantly lower increase of body weight in patients with type 2 diabetes mellitus in comparison with patients treated with insulin NPH.

Ročník 2005  Témy časopisu Internal medicine 11 / 2005

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doc. MUDr. Ján Staško, PhD.
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2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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