Téma: Overview works

Diabetes mellitus 1 and 2 type and their modern therapy

Emil Martinka, Silvia Dókušová, Radovan Plášil, Peter Lakota, Ján Čulák

There is only few branches of medicine which report such an amount of new knowledge of pathogenesis and therapy of DM. It is connected with medical and universal severity and at the same time with multifactority and diversity of the disease. DM is not a single disease with a simple cause, homogenous symptoms and methods of treatment. Actually, it is a large group of diseases. The most frequent and the most important cause of hyperglycaemia is insufficient or extincted insulin production (typical for diabetes mellitus 1 type DM - 1 ) and lower sensitivity of tissues to insulin together with functional disorders of insulin secretion (typical for diabetes mellitus 2 type DM - 2).Both groups of disorders result from more mechanisms many of them genetically determined. Genetic predisposition is stronger and pathogenesis is more multiform in DM - 2 than in DM-1. While in DM – 1 the cause is more or less clarified (it is an autoimmune destruction of β-cells of the pancreas in genetically predisposed terrain.) in DM - 2 the pathogenetic mechanism is only outlined (lower sensitivity of tissues to insulin and functional disorders of insulin secretion). Problem of different therapeutic approach to single types of the disease is considered.While in DM - 1 the main disorder is insufficient insulin production the only effective therapy is its exogennous substitution. Insulintherapy has recently reported several crucial knowledge that resulted in development of insulin analogues (synthetically prepared insulins with intentionally changed sequence of aminoacids) that are more suitable for organism physiology than conventional substances and enable to reach better glycaemic control in a larger proportion of patients with a lower risk of adverse effects. The key effort in the last years in DM - 2 therapy has been aimed at insulin resistance affecting with outlook of improvement of cardiovascular prognosis. This resulted in development of glitasons and glitasars that affect expression of genes and their products present in metabolism of fats, carbohydtrates and further processes affecting cardiovascular risk. Further new groups of drugs are expected to be launched in several months. The problem of DM therapy is getting more effective on one side but on the other side it is more complicated.

Ročník 2005  Témy časopisu Internal medicine 12 / 2005

CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
prof. MUDr. Juraj Payer, CSc., FRCP

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

EDITOR-IN-CHIEF
Eva Stachová
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OVERVIEW PAPERS
The latest knowledge on disease and disease groups aetiology, pathogenesis, diagnoses and therapy. Maximum size is 7 pages (font size 12, line spacing 1.5) with maximum six pictures (graphs). In case of more extensive theme it is possible to divide the paper to several parts after agreement with editorial office. Write the article with emphasis on its practical usage for out-patient internists and general practitionrs.

CASE STUDY
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DIAGNOSTIC AND THERAPEUTICAL ALGORITHMS
Diagnosis and therapy processed into tables and schemes, with minimum text, with emphasis on conciseness and clarity.

MISCELLANEOUS
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APPENDIX - GENERAL MEDICINE
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2. Summary - concise content summary in the extent maximum 10 lines (only at overview papers, case studies and Appendices - General Medicine). Write in 1st or 3rd person singular or plural (unify according the type of an article).

3. Key words - in the extent of 3-6 (only for overview papers and Appendices - General Medicine). 4. English translation: paper title, summary, key words (only at overview papers, and Appendices - General Medicine)

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6. Bibliography
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Examples of citations:
1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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Due to publishing of autodidactic tests it is necessary to add 4 questions to your article and 4 answers with marking of one correct answer, e.g.: Which of following factors is not related to rosacea?
a. genetic predisposition
b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor


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All published papers are paid.

Due to practical focus of the journal we would like to ask you to write the paper comprehensively, with emphasis on practical use of provided information in out-
patient internists and general practitioners.


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