Téma: Overview works

The scoring systems of chronic hepatitis in liver biopsy - a role and application in practice

Vladimír Bartoš, Ľudovít Lauko, Dušan Krkoška, Renáta Szépeová

Liver biopsy is a standard examination in diagnostic process of hepatic diseases. It is particularly necessary for assessment of grading and staging of chronic hepatitis. Although many histological scoring systems have been proposed, numerical scoring of liver biopsies will continue to have a place in the context of clinical trials. The Ishak score is used in many medical centers. According to this system, the degree of necroinflammatory activity is assessed as minimal (1 - 3 points), mild (4 - 8 points), moderate (9 - 12 points) and severe (13 - 18 points) and the degree of fibrosis is similary assessed (1 - 6 points). The authors of article present a basic informations about history and application of scoring systems at present and describe their advantages and disadvantages. The note, that semiquantitative histological scoring is particularly helpful in clinical studies and research on chronic hepatitis and is less relevant in routine clinical practice. Traditional descriptive reports should remain the basic part of routine histomorphological examination.

Ročník 2006  Témy časopisu Internal medicine 1 / 2006

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MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
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doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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