Téma: Clinical pharmacology

Aspirin resistance

Radomír Nosáľ

Acetylsalicylic acid is economically the most advantageous drug for secondary prevention of cardiovascular diseases inspite of its often failure. This is linked to series of factors being in on reccurrent little strokes in patients taking aspirin including various predispositions, smoking, drugs interactions and aspirin resistance of its own. This phenomenon is regarded as measurable persistent blood platelet activation found in patients taking therapeutic doses of aspirin and disturbance of its pharmacologic effectiveness to the function of platelets as well as low clinical response manifested by the risk of reccurrent little strokes in treated patients. Recent studies have reported that the prevalence of aspirin resistance is higher in patients with acute coronary syndrome (40 %) than in patients with stable coronary diseases (up to 30 %).

Ročník 2006  Témy časopisu Internal medicine 1 / 2006

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prof. MUDr. Ivica Lazúrová, CSc. FRCP

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MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
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doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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