Téma: Overview works

Fever in a patient with neutropenia

Martin Mistrík, Eva Demečková, Eva Bojtárová, Pavol Kotouček, Jana Tóthová, Katarína Bocková, Zuzana Michalovičová, Branislav Czako

Prolonged neutropenia (neutrophil count less than 0,5x109/l) is a major risk factor for the development of infections. The signs and symptoms of infection are often absent or muted in the presence of neutropenia, but fever remains an early, although nonspecific, sign. Nowadays is rare for acute leukemia or transplanted patients to die from infection during neutropenia. There are effective methods to anticipate, prevent, and manage infectious complications in neutropenic patients that improve outcomes. Appropriate empirical antimicrobial therapy reduces morbidity and improves febrile neutropenia outcome. Increasingly, however, it is clear that managing infections in neutropenic patients is a dynamic process with the appearance of new pathogens, the emergence of antibiotic-resistant organisms, and the improved stratification of patient’s infection risk. Therefore effective strategies in febrile neutropenia clinical management has to continue to evolve.

Ročník 2006  Témy časopisu Internal medicine 3 / 2006

CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
prof. MUDr. Juraj Payer, CSc., FRCP

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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d. endothelial growth factor


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