Dagmar Mičeková, Ivan Rybár, Vanda Mlynáriková
Sjögren’s syndrome is a systemic disorder of connective tissues characterized especially by the decreased functioning of exocrine glands. This disorder may appear separately as a primary Sjögren’s syndrome or in connection with other inflammatory rheumatic disorders as a secondary Sjögren’s syndrome. Chronic plasmocellular infiltration initiates disorder of secretion especially in salivary and lacrimal glands resulting in xerostomy and xerophtalmy. Glands of gastrointestinal system and pulmonary tract, skin and vaginal mucosa may also be affected. The most often extraglandular manifestations of the primary Sjögren’s syndrome include skin vasculitis, Raynaud’s phenomena, functional renal abnormalities, neuropathy and arthritis symptoms.