Téma: Overview works

Utilizing of nephroprotective effects of ace inhibitors and sartans - when are they indicated?

Silvester Krčméry, Rastislav Tahotný, Klára Soláriková

Utilizing of ACE inhibitors and AT1 blockers for receptors of angiotensin II (sartans) are reported in literature as prevention and deceleration of renal diseases progression. Differences in efficacy among a great number of ACEI molecules result from various pharmacokinetic features and occurrence of adverse effects. More clinical studies suggest combined therapy of ACEI and sartans as more efficient than monotherapy for proteinuria reduction and deceleration of renal insufficiency progression in patients with chronic renal diseases. In the light of present knowledge candidates for combined therapy are only some groups of patients with chronic nephropathy (patients with proteinuria > 1 g/24 hrs, with progressive loss of glomerular filtration within chronic glomerulonephritis activity, diabetic nephropathy, etc.). Potential risk of combination of ACEI and sartans is worsening of renal anemia and hyperkalemia.

Ročník 2006  Témy časopisu Internal medicine 10 / 2006

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prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
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MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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d. endothelial growth factor


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