Téma: Overview works

Genetic background of type 2 diabetes mellitus

Martina Dobríková, Alena Stančáková, Martin Javorský, Ivan Tkáč

Type 2 diabetes mellitus (DM2) is a complex illness where the role of more genes is very important. Effect of particular genes is not that big but their mutual interaction together with environmental factors can increase the risk of development of DM2. Results of metanalyses monitoring the association of polymorphisms of candidate genes with the risk of development of diabetes show 1.1 to 1.8 -fold increase of the risk in carriers of risk aleles of particular polymorphisms. Pathogenetically they are genes affecting mostly insulin secretion or insulin sensitivity. The strongest association of genes affecting insulin secretion were detected with a gene coding transcription factor 7 (TCF7L2) and genes coding sulphonylures receptor (KCNJ11, ABCC8).Genes affecting insulin sensitivity were associated with a gene PPARG coding peroxizome proliferator activated receptor γ (PPARγ). The aim of research of DM2 genetic background is to understand genetic and molecular aetiology of this frequent metabolic disease that result may in more efficient treatment, prevention, prediction of future complications and prognosis.

Ročník 2007  Témy časopisu Internal medicine 3 / 2007

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REPRESENTATIVE OF CHAIRMAN
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MEMBERS OF THE EDITORIAL BOARD
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MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor


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