Téma: Overview works

Management of patients with high cardiometabolic risk what is cardiometabolic risk and how it is determined in clinical practice? - part 1

Slavomíra Filipová

Simultaneous presence of the risk factor cluster, the frequent situation in the individual patient, represents every-day problem for the diagnostics and treatment of various serious clinical conditions together (arterial hypertension, impairment of glucose tolerance, type 2 diabetes mellitus, obesity, abnormalities in lipid spectrum, smoking abuses, physical inactivity and other risk factors). The current international guidelines, Slovak Lipid consensus-2 and its Actualization represent the background of the stratification. The basic data of cardiometabolic risk profile may be determined by using SCORE Card ESC and by measuring the waist circumference. Actual scientific knowledge concerning the central abdominal type of obesity change the view on the evaluation of overweight, obesity, especially in the high risk individuals. Adipocytes as the endocrine and metabolic active cells significantly affect the metabolic status and these activities elevate the effect on other risk factors for the atherosclerotic process development. In the paper we analyze the relations of type 2 diabetes mellitus, renin-angiotensin-aldosterone system, arterial hypertension, effect of endocanabinoid system and metabolic syndrome on atherosclerotic progress. The pathophysiologic connection of cardiovascular and metabolic risk, currently called “cardiometabolic risk” represents not only the research interest but also every-day need of clinical practice during the patients’ evaluation and management with risk factors.

Ročník 2007  Témy časopisu Internal medicine 7 / 2007

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REPRESENTATIVE OF CHAIRMAN
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MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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d. endothelial growth factor


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