Téma: Overview works

Anew aspects of obesity obesity as a dominant phenomenon in etiopathogenesis of metabolic syndrome

Juraj Hrnčiar

Obesity is a pandemic, civilization, mass disease affecting increase of insulin resistance in etiopathogenesis of phenomena of insulin resistance syndrome and in acceleration of the process of atherothrombogenesis. In expanded abdominal adipose tissue in android obese people the processes of production (adiponektine, leptine, resistine and cytokines), modification (steroid hormones) or utilization of numerous hormone regulating signals occur. This means that adipose tissue is not only a passive store of energy reserves but also a very active tissue in energy homeostasis. Adipose tissue is involved in formation and modification of metabolic syndrome phenomena (insulin resistance, hypertension, dyslipoproteinemia, DM 2, hirsutism with cycle disorders). Obesity dominates together with hyperinsulinism compensating IR in background of etiopathogenesis of metabolic syndrome phenomena and following cardiovascular diseases that are the main cause of morbidity, invalidity and mortality.

Ročník 2007  Témy časopisu Internal medicine 9 / 2007

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MEMBERS OF THE EDITORIAL BOARD
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MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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