Téma: Overview works

Amylin and its role in regulation of postprandial glycemia

Pavel Babušík

Amylin (islet amyloid polypeptide) is a peptide produced by pancreatic β-cells and released to the circulation together with insulin in response to food intake. Amylin is a neuroendocrine hormone acting mainly via area postrema. Amylin exerts fast and short lasting decrease in food intake, supresses postprandial glucagon and pancreatic enzymes secretion, decreases the rate of gastric emptying and gastric acid production. Thus amylin effectively regulates postprandial surge of glucose and other nutrients to the circulation. Amylin appears to be inevitable complementary factor to insulin, both acting simultaneously. In diabetics with impaired β-cell function secretion of both insulin and amylin are affected with serious consequencies for adequate compensation of diabetes. These facts have important clinical impact and a synthetic human amylin analogue was introduced to the treatment of specific cases of type 1 and type 2 diabetes.

Ročník 2007  Témy časopisu Internal medicine 10 / 2007

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MUDr. Viera Fedelešová, CSc.
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prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
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prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
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2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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