Téma: Overview works

Defect of insulin secretion - necessary condition for clinical manifestation of type 2 diabetes mellitus

Zbynek Schroner

Insulin resistance and the defect of insulin secretion are two basic pathogenic mechanisms in the development of type 2 diabetes mellitus. The presence both of these defects is necessary for clinical manifestation of type 2 diabetes mellitus. Due to progressive loss of function and number of B-cells insulin secretion is declined. Insulin resistance, if it is not intervened, remains unchanged in the course of the disease, so gradual increasing of fasting and postprandial glycemias is clear outcome of relative and later also absolute deficiency of insulin. Exact causes of defect of insulin secretion in the course of type 2 diabetes mellitus are not completely known. A number of factors have been posited to contribute to the decline of insulin secretion. These include: genetic factors, glukotoxicity, lipotoxicity, oxidative stress, defects of secretion of glukagone like peptid (GLP-1), amyloidosis, increased apoptosis of B-cells.

Ročník 2007  Témy časopisu Internal medicine 11 / 2007

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prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
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MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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c. propionibacterium acnes
d. endothelial growth factor


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