Téma: 

Scientific programme delfín – understanding the newest guidelines for arterial hypertension therapy

Daniel Pella, Viola Mechírová

Despite large improvement in diagnostic process and therapy remain arterial hypertension therapy still a major public health concern. In Slovakia, one of the reasons of this situation is lack of pharmacoepidemiological data about arterial hypertension. Scientific programme DELFÍN (for evaluation of therapeutic effect in not controlled hypertensive patients and hypertensive ones who did not tolerate current therapy) was designed with the aim to get pharmacoepidemiological data about arterial hypertension. Patients enrolled into the programme were subsequently treated with perindopril arginine in order to evaluate its efficacy and safety. Statistically significant decrease of systolic blood pressure from 157,47 ± 13,86 mmHg na 135,11 ± 11,24 mmHg (p < 0,00001) was found in the group of 2016 patients after 3 months of therapy and diastolic blood pressure from 95,94 ± 7,66 mmHg to 83,15 ± 6,81 mmHg (p < 0,00001). Interesting finding was significant reduction of heart rate (showing the role of sympathetic nervous system in the pathogenesis of arterial hypertension) from 76,40 ± 8,81/min. to 73,07 ± 6,52/min. (p < 0,00001). Adverse effects (not serious) were observed only in 2 % of treated patients which confirm together with excellent compliance to therapy significant role of perindopril in modern arterial hypertension management.

Ročník 2007  Témy časopisu Internal medicine 11 / 2007

CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
prof. MUDr. Juraj Payer, CSc., FRCP

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

EDITOR-IN-CHIEF
Eva Stachová
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1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor


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