Téma:  Case Studies

Intermittent cushing’s syndrome

Marek Felšöci, Hedviga Wagnerová, Ivica Lazúrová

Intermittent (cyclic) Cushing’s syndrome (CS) is a rare disease, characterized by repeated episodes of hypercortisolism interrupted by periods of normal cortisol secretion. Generally accepted criteria to diagnose cyclic CS include three peaks and two troughs of cortisol production. The cycle frequency may intra- and interindividually vary from 10 times in 3 months to twice in 5 years. Up to now only 65 cases were reported worldwide. In 54 % of all cases disease is determined by a pituitary ACTHsecreting adenoma, in 26 % by an ectopic ACTH-producing tumour and in about 11 % by an adrenal tumour, the remainder are unclassified. The pathophysiology of disease is largely unknown. The clinical signs of cyclic CS are similar to noncyclic and can be either partial or fully manifestated. Thanks to fluctuating clinical picture and time-depending biochemical findings intermittent CS is extremely hard to diagnose. We report a case of a 66-year-old woman with a severe hypercortisolism and spontaneous regression within three months.

Ročník 2008  Témy časopisu Internal medicine 2 / 2008

CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
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MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
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doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
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3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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