Téma: Clinical pharmacology

The place and perspectives of the first renine inhibitor aliskiren in clinical practice

Peter Jonáš

Therapeutic modulation of the renin angiotensin-aldosterone system (RAAS) plays the key role in effective hypertension management as well as in the cardiovascular and renal protection. Aliskiren is the first direct renin inhibitor that has been approved by the European Medicines Agency for the treatment of hypertension. Aliskiren is orally available highly specific and effective inhibitor of human renin with multiple favourable pharmacologic properties. Good antihypertensive efficacy in monotherapy and comparison with some of the basic antihypertensive class representatives (HCTZ, ramipril, valsartan) and its wide combination potential with other antihypertensives has been confirmed within the program of clinical development. Aliskiren has placebo-like tolerability in monotherapy and is well tolerated in combinations. The ASPIRE HIGHER clinical research program is evaluating the organ protection potential and clinical outcomes benefits of direct renin inhibition with aliskiren and may broaden its future clinical use in new indications.

Ročník 2008  Témy časopisu Internal medicine 7 / 2008

CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
prof. MUDr. Juraj Payer, CSc., FRCP

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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c. propionibacterium acnes
d. endothelial growth factor


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