Téma: 

Effect of metabolic syndrome to the therapy with nitrendipine in patients in the middle and higher age with arterial hypertension

Viera Kosmálová, Viera Husárová, Eva Hirnerová, Ján Lietava

Components of metabolic syndrome as abdominal obesity and/or insulin resistance could hamper a hypotensive effect of antihypertensive medication. We evaluated interaction of several markers of cardiometabolic risk with hypotensive effect of short-term therapy with nitrendipine in 3015 patients (39.8 % males and 60.2 % females) aged 61.8±11.6 years (19-95 years) with moderate to severe arterial hypertension. Out-ward patients with arterial hypertension exhibited high prevalence of metabolic syndrome - 48.3 % with significant prevalence in females 53.7 % vs. 40.2 %. Short-lasting therapy with nitrendipine caused important decrease of blood pressure and significant reduction of absolute risk according to SCORE about 36.2 % Overweight, obesity, abdominal obesity, hypertriglyceridemic waist, metabolic syndrome or diabetes mellitus did not exhibit negative impact on effectiveness of nitrendipine.

Ročník 2008  Témy časopisu Internal medicine 9 / 2008

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prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
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MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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