Téma: Overview works

Autoimmune thyreoditis and systemic disease of connective tissue

Ivica Lazúrová, Karim Benhatchi

Autoimmune thyreoditis (AIT) is considered as the most frequent organic specific autoimmune disease. It is also the commonest cause of goiter in countries with lack of iodine. It is known that AIT is often associated with the presence of other organic non-specific and organic specific auto-antibodies. The most frequent organic non-specific antibodies are antinuclear antibodies (ANA). Their clinical significance in AIT has not been clear so far. In patients with AIT clinical rheumatic manifestations develop which are associated with dysfunction of thyroid gland, with thyroidal autoimmunity and they can also be symptoms of intercurrent systemic disease of connective tissue. Proved association is that of AIT with Sjögren´s syndrome, rheumatoid arthritis and SLE. Presumptive association is that of AIT with systemic sclerosis and polymyositis. Significantly higher prevalence of AIT was proved in patients with systemic diseases of connective tissue which results in need of standard screening of thyroidal autoimmunity mostly in patients with SLE, rheumatoid arthritis and Sjögren´s syndrome.

Ročník 2008  Témy časopisu Internal medicine 11 / 2008

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prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
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MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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c. propionibacterium acnes
d. endothelial growth factor


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