Téma: 

Cardiovascular risk stratification and evidence based medicine hypertension treatment results of the scientific programme falco

Daniel Pella

Following the latest guidelines the treatment of arterial hypertension is aimed not only at simple reduction of blood pressure but at prevention of the cardiovascular complications that are known to accompany the high blood pressure. The patients were stratified in the scientific programme FALCO (StratiFikácia kArdiovaskulárneho rizika a Liečba hypertenzie založená na mediCíne dôkazOv) according newest European ESH/ESC guidelines for management of arterial hypertension 2007 and in consequence the effect of three months therapy with fixed combination of perindopril arginine with indapamide were assessed. The objective of the scientific programme FALCO was to demonstrate that above mentioned fixed combination therapy has the same safety and effectivity none the less in the whole group of patients (irrespective of cardiovascular risk) but also in the group of patients with high cardiovascular risk. Systolic blood pressure decreased statistically significantly from 157.50 ± 14.53 mmHg to 132.25 ± 10.31 mmHg (p < 0.00001) and diastolic blood pressure from 95.73 ± 8,39 mmHg to 81.19 ± 6.35 mmHg (p < 0.00001) in the whole group of patients (n = 2,246) after 3 months of therapy. Statistically significant decrease of heart rate from 75.44 ± 9.75/min. to 70.86 ± 6.94/min. (p < 0.00001) was observed as well. Statistically comparable decrease of both systolic blood pressure (from 158.86 ± 15.09 mmHg to 132.83 ± 10.06 mmHg; p < 0.00001) and diastolic blood pressure (from 95.73 ± 8.39 mmHg to 81.19 ± 6.35 mmHg; p < 0.00001) in the group of high risk patients were found. Decrease of heart rate was similar from 75.46 ± 10.18/min. to 70.88 ± 7.00/min. (p < 0.00001). Adverse effects were very rare, mild and comparable in the both groups. In conclusion, fixed combination therapy with perindopril arginine and indapamide was equally effective and safe in patients with arterial hypertension in all categories of cardiovascular risk.

Ročník 2009  Témy časopisu Internal medicine 1 / 2009

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prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
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MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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