Ján Staško, Pavol Hollý, Miroslava Dobrotová, Peter Kubisz
Thrombophilic states are inherited or acquired hemostatic disorders pathophysiologically and statistically associated with higher risk of thrombosis. Their most important clinical manifestation is venous thromboembolism (VTE). Approximately 50 % of patients have a spontaneous episode of VTE in absence of provoking stimulus and diseases which suggests an importance of inherited thrombophilic states in pathogenesis of VTE. In this article there is a brief review of the most frequent thrombophilic states, their relation to venous and arterial thrombosis and the impact of thrombophilia diagnosis is stressed because of its crucial role for the accurate decision about appropriate thromboprophylaxis and treatment of thrombosis.