Téma: Overview works

Renin-angiotensin-aldosteron system inhibition and type 2 diabetes mellitus

Miriam Kozárová, Martin Javorský, Ivan Tkáč

Diabetes mellitus is serious worldwide mediacal problem. Dietary and regime changes play an important role in preventive programs of type 2 diabetes mellitus and they are quite effective. On the other side, low adherence of majority of patients to them is known. Having in mind high prevalence of arterial hypertension in patients with overweight or obesity, it is interesting to consider possible effect of angiotensin converting enzyme inhibition and angiotensin II blockade on incidence of type 2 diabetes in patients with arterial hypertension and/or chronic heart failure. Mechanisms mediating preventive effects of reninangiotensin- aldosteron system inhibition in relation to development of type 2 diabetes mellitus are probably complexly associated with pathophysiology of the disease.

Ročník 2009  Témy časopisu Internal medicine 9 / 2009

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MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
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doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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d. endothelial growth factor


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