Ján Staško, Lenka Bartošová, Pavol Hollý, Daniela Kotuličová, Peter Kubisz
Objective of the article is to review the current knowledge on the etiopathogenesis, clinical manifestation, diagnosis, and treatment of disseminated intravascular coagulation (DIC). DIC, as a complication of other underlying disease, can lead to significant morbidity and mortality in particular related to organ dysfunction and bleeding. The diagnosis of DIC is based on clinical finding, routinely available laboratory tests and scoring system. Treatment of DIC may be directed on replacement of platelets and coagulation factors, anticoagulant treatment, and restoration of anticoagulant pathways. Progress into the knowledge about pathogenesis of DIC has resulted in better strategies for clinical management, including up-to date diagnostic criteria and targeted treatment.