Téma: Overview works

Insulin detemir in actual clinical practice – predictive®, and titrate®, studies

Zbyněk Schroner, Vladimír Uličiansky

The aim of the multicenter, open-label, observational study PREDICTIVE® was to assess safety and efficacy of insulin detemir in both type 1 and 2 diabetes patients in actual clinical practice. The results of the European cohort of PREDICTIVE® after three-month therapy with insulin detemir found it to be an efficacious product allowing substitution of basal insulin secretion. Its administration was associated with a minimal occurrence of adverse events (especially major hypoglycemic episodes) together with a low within-patient fasting glucose variability and more predictable therapeutic effect. The European cohort of the PREDICTIVE® study confirmed the results of clinical randomised trials, that the therapy with insulin detemir does not cause body weight gain. Moreover, body weight reduction in type 1 and 2 diabetes patients was observed within this study. Results from the six-month insulin detemir therapy provide evidence on the long term safety and efficacy of this insulin. Results of the TITRATE® study showed, that lowering the fasting glucose target using a self-directed titration algorithm with once-daily detemir is safe and efficacious.

Ročník 2010  Témy časopisu Internal medicine 3 / 2010

CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
prof. MUDr. Juraj Payer, CSc., FRCP

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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OVERVIEW PAPERS
The latest knowledge on disease and disease groups aetiology, pathogenesis, diagnoses and therapy. Maximum size is 7 pages (font size 12, line spacing 1.5) with maximum six pictures (graphs). In case of more extensive theme it is possible to divide the paper to several parts after agreement with editorial office. Write the article with emphasis on its practical usage for out-patient internists and general practitionrs.

CASE STUDY
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DIAGNOSTIC AND THERAPEUTICAL ALGORITHMS
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- explain abbreviations always when first used


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3. Key words - in the extent of 3-6 (only for overview papers and Appendices - General Medicine). 4. English translation: paper title, summary, key words (only at overview papers, and Appendices - General Medicine)

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6. Bibliography
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Examples of citations:
1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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a. genetic predisposition
b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor


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Due to practical focus of the journal we would like to ask you to write the paper comprehensively, with emphasis on practical use of provided information in out-
patient internists and general practitioners.


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