Téma: Overview works

Gastric malt lymphoma – the use of flow cytometry for its diagnosis

Ľubica Váleková, Jana Fedorová, Jana Božíková, Lukáš Plank, Peter Szépe, Tomáš Balhárek, Ján Staško, Peter Kubisz, Ján Hudeček

MALT lymphomas (Mucosa - Associated Lymphoid Tissue) are rare neoplasms that arise from a malignant transformation of mucosa lymph tissue MALT. Accounting for about 5 % of all non-Hodgkin lymphomas, more than 2/3 of them occur in gastrointestinal tract. Gastric infection of Helicobacter pylori (HP) plays an important role in its pathogenesis. To determine the diagnosis of MALT lymphoma it is essential to perform an endoscopic examination followed by the histological examination of a bioptic specimen (morphology and immunohistochemistry). Flow cytometry greatly contributes to the diagnosis and is usefull in verification of tumor population monoclonality (unimodal expression of one type of light chains, kappa or lambda) and in determination of B-cell antigen profile associated with this diagnosis (CD19+, CD20+, CD22+, CD24+, CD79a+, HLA-Dr+).

Ročník 2010  Témy časopisu Internal medicine 5 / 2010

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prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
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prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
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3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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