Téma: Overview works

Immune thrombocytopenia - differential diagnosis and management of thrombocytopenia

Mária Hulíková

Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by isolated thrombocytopenia, which may be caused due to increased platelet destruction mediated by auto antibodies that target several platelet glycoproteins (GPIIb/ IIIa and GP Ib/IX). ITP pathogenesis is multifactorial. In thrombocytopenia, in addition to destruction of platelets, there is also involved a disorder maturation of megacaryocytes, decreased production of megacaryocytes and platelets, megacaryocytes inadequate response to a reduction in peripheral blood platelets and the relative lack of endogenous trombopoietin (TPO). Diagnosis of ITP is based primarily on the exclusion of other causes of thrombocytopenia and includes anamnesis, clinical features, physical and laboratory examinations. The main goal of treatment is to ensure such an amount of platelets which will prevent serious bleeding. Treatment strategy is aimed at suppression of antibody production, to eliminate points of platelets termination and stimulate the platelet production.

Ročník 2010  Témy časopisu Internal medicine 11 / 2010

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MEMBERS OF THE EDITORIAL BOARD
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MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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d. endothelial growth factor


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