Téma: 

Fixed combination of antihypertensive drugs in the treatment of arterial hypertension – not only blood pressure decrease, but also comprehensive cardiorenal protection results of the scientific programme dual protection

Daniel Pella

Fixed combination of perindopril arginine and indapamide has been proven by extensive evidence based medicine. Many clinical studies confirmed significant antihypertensive effect of this combination in a broad dosage variability. Moreover, comprehensive cardiorenal protection has been validated (mainly in clinical studies ADVANCE, PREMIER, PROGRESS, PICXEL, HYVET and others). The objective of the scientific programme DUAL PROTECTION (ReDUkcia kArdiovasku- Lárneho rizika a zlepšenie kvality života Pacientov s aRtériOvou hyperTEnziou pomoCou ekfekTÍvnej Originálnej aNtihypertenzívnej liečby) was to demonstrate antihypertensive efficacy of fixed combination of perindopril arginine and indapamide irrespective of cardiovascular risk and associated comorbidities. Systolic blood pressure decreased statistically significantly from 155.99 ± 12.24 mmHg to 131.11 ± 9.14 mmHg (p < 0.001) and diastolic blood pressure from 94.80 ± 7.61 mmHg to 80.50 ± 5.67 mmHg (p < 0.001) in the whole group of patients (n = 2,468) after 4 months of therapy. The rates of blood pressure decrease were comparable in various subgroups of patients irrespective of presence of type 2 diabetes, microalbuminuria or left ventricular hypertrophy. Adverse effects were very rare and mild. Moreover, there were no significant changes of evaluated labaratory parameters observed during the whole period of scientific programme. Patient´s quality of life (evaluated by questionnaire method) significantly improved at the end of period of scientific programme in comparison with baseline visit (p < 0.001). In conclusion, fixed combination therapy with perindopril arginine and indapamide was equally effective and safe in patients with arterial hypertension in all categories of cardiovascular risk, irrespective of associated comorbidities.

Ročník 2010  Témy časopisu Internal medicine 11 / 2010

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MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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