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Časopis Internal medicine – Článok Results of the programme dual protection 2010 – cardiovascular risk reduction and quality of life improvement in patients with arterial hypertension

Internal medicine

Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné
Téma: 

Results of the programme dual protection 2010 – cardiovascular risk reduction and quality of life improvement in patients with arterial hypertension

Daniel Pella, Lucia Jedličková, Lucia Merkovská, Rastislav Šidlo

Programme DUAL PROTECTION 2010 (ReDUkcia kArdiovaskuLárneho rizika a zlepšenie kvality života Pacientov s aRtériOvou hyperTEnziou pomoCou ekfekTÍvnej Originálnej aNtihypertenzívnej liečby) was focused on cardiovascular risk reduction and quality of life improvement in hypertensive subjects. Adverse effects of antihypertensive drugs are quite common and they are associated with decreased therapy compliance or even lead to withdrawal of antihypertensive treatment. That is why there is a need for new therapeutic approach with not only the lowest burden of side effects, but with significant antihypertensive action. This programme was based on our previous experience in DUAL PROTECTION where we used successfully fixed combination of perindopril arginine and indapamide. We would like to prove these benefits in subsequent programme. Systolic blood pressure decreased statistically significantly from 159.1 ± 12.83 mmHg to 129.97 ± 6.89 mmHg (p < 0.0001) and diastolic blood pressure from 96.52 ± 7.88 mmHg to 79.72 ± 5.28 mmHg (p < 0.0001) in the whole group of patients (n = 2,476) after 4 months of therapy. The rates of blood pressure decrease were comparable also in high-risk groups of patients with presence of microalbuminuria or left ventricular hypertrophy or diabetes type 2. We observed a significant trend towards more pronounced decrease of blood pressure along with increasing number of hypertension risk factors. Adverse effects were very rare and mild. Moreover, there were no significant changes of evaluated laboratory parameters observed during the whole period of programme. Patient´s quality of life (evaluated by simple questionnaire method) significantly improved at the end of programme in comparison with baseline visit (p < 0.0001). We confirmed beneficial therapeutic effects of fixed combination perindopril arginine and indapamide in the programme DUAL PROTECTION 2010 in accordance with results achieved in programme DUAL PROTECTION (all together nearly 5,000 patients). Fixed combination therapy with perindopril arginine and indapamide was equally effective and safe in patients with arterial hypertension in all categories of cardiovascular risk, irrespective of associated comorbidities.

arterial hypertension, perindopril arginine, indapamide, DUAL PROTECTION 2010
Interná med. 2011; 11 (11): 495-501

Ročník 2011  Témy časopisu Internal medicine 11 / 2011

Overview works

Adriena Sakalová, Mikuláš Hrubiško
Anna Remková
Ivana Plameňová, Ján Staško
Jozef Fekete

Daniel Pella, Lucia Jedličková, Lucia Merkovská, Rastislav Šidlo

Marta Petríková, Miroslav Kubeš, Peter Takáč, Milan Kozánek

Milan Žuffa, Milan Zemančík, Ivan Rusnák, Alexander Schóber
Nie sú dostupné žiadne voľne dostupné články
CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
prof. MUDr. Juraj Payer, CSc., FRCP

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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c. propionibacterium acnes
d. endothelial growth factor


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patient internists and general practitioners.


Send contributions in the e-mail to the address: stachova@amedi.sk
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné