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Časopis Internal medicine – Článok Pulse 2011 – results of the clinical programme focused on quality of life improvement in patients with stable angina pectoris

Internal medicine

Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné
Téma: 

Pulse 2011 – results of the clinical programme focused on quality of life improvement in patients with stable angina pectoris

Daniel Pella, Rastislav Šidlo

Clinical programme PULSE 2011 (Klinický Program zameraný na zlepšenie kvality života U pacientov Liečených pre Stabilnú angínu pEktoris) was focused on quality of life improvement (evaluated by number of angina pectoris attacks per week and number of sublingual forms of nitroglycerin used) in patients with stable angina pectoris. Treatment of choice was heart rate reduction by fortified treatment. We have evaluated patients with documented coronary artery disease with syndrome of stable angina pectoris despite previous pharmacological treatment, including betablockers (as far as they were contraindicated or not tolerated due to adverse effects). Heart rate over 70 beats /min. was a key inclusion criterion. There were 1733 patients included into the programme. Ivabradine (Procoralan®) in the dose 2x5 mg daily was added to the treatment with optional up or down-titration during the programme course. After 3 months of therapy we observed not only statistically significant decrease of heart rate from 84.42 ± 9.77 beats/min. to 64.85 ± 6.10 beats/min. (p<0.0001), but above all, statistically significant decrease of angina pectoris attacks from 3.72 ± 3.11 to 0.86 ± 1.06 per week (p<0.0001) and significant reduction of sublingual nitroglycerin administrations from 3.19 ± 3.04 to 0.62 ± 1.07 per week were observed (p<0.0001). Quality of life of the patients (evaluated by simple questionnaire) significantly improved at the end of the programme in comparison with baseline visit (p<0.0001). Moreover, we found significant decrease of pain threshold and its intensity classified by CCS (Canadian Cardiovascular Society). We have confirmed that ivabradine (Procoralan®) improved quality of life in patients with stable angina pectoris by significant reduction of frequency and intensity of angina pectoris attacks.

stable angina pectoris, ivabradine, quality of life, PULSE 2011
Interná med. 2012; 12 (1): 37-41

Ročník 2012  Témy časopisu Internal medicine 1 / 2012

Overview works

Ivica Lazúrová, Ingrid Dravecká
Anna Remková
Svetlana Bodíková, Veronika Pokorná
Mikuláš Szakács, Peter Mitro
Anna Stecová, Edita Dobáková, Eva Bátorová
Marián Mokáň, Jozef Polko, Peter Galajda

Štefan Farský

Daniel Pella, Rastislav Šidlo
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REPRESENTATIVE OF CHAIRMAN
prof. MUDr. Juraj Payer, CSc., FRCP

MEMBERS OF THE EDITORIAL BOARD
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MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
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doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
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2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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Send contributions in the e-mail to the address: stachova@amedi.sk
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné