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Časopis Internal medicine – Článok The effect of liraglutide on the metabolic control of obese type 2 diabetics in clinical practice

Internal medicine

Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné
Téma: Original Works

The effect of liraglutide on the metabolic control of obese type 2 diabetics in clinical practice

Ľubomíra Fábryová

The goal was to assess the impact of 6 month treatment with liraglutide and maximum tolerated dose of metformin in 30 obese type 2 diabetic patients on cardiometabolic comprehensive management: weight loss, body mass index (BMI) and waist circumference, glycaemic control (fasting glucose, postprandial blood glucose and glycated haemoglobin (HbA1c), systolic and diastolic blood pressure, lipid profile (TC, LDL-C, triglycerides, HDL-C) and atherogenic index of plasma (AIP) as a significant predictor of cardiovascular risk. After 6 months of treatment with liraglutide and maximum tolerated dose of metformin in the study group we observed a statistically significant difference in weight loss (-3,9 kg), BMI (-1.6 kg/m2) and waist circumference (-3,2 cm). There was a statistically significant decrease in fasting plasma glucose (-2,7 mmol/l), postprandial glucose (-3,2 mmol/l) and glycosylated haemoglobin (-1,1 %). We have not observed a statistically significant difference in systolic and diastolic blood pressure, as well as in total and LDL-cholesterol. However, during treatment, there was a shift to less atherogenic lipoprotein phenotype (TAG decrease and HDL-C increase, decreased AIP), with statistically significant differences from baseline. Treatment with liraglutide in combination with metformin resulted in a significant improvement in cardiometabolic risk profile type 2 diabetic patients; it was well tolerated without increasing the risk of hypoglycaemia.

obesity, type 2 diabetes mellitus, liraglutide
Interná med. 2012; 12 (7-8): 296-303

Ročník 2012  Témy časopisu Internal medicine 7 / 2012

Overview works

Mária Hulíková
Mária Borsányiová, Zdenka Sobotová, Renáta Kissová, Cyril Klement, Shubhada Bopegamage
Andrej Dukát, Peter Gavorník, Lucia Mistríková, Dávid Baláž, Ján Gajdošík, Ľudovít Gašpar

Original Works

Ľubomíra Fábryová

Clinical pharmacology

Beata Mladosievičová, Ján Rajec
Nie sú dostupné žiadne voľne dostupné články
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REPRESENTATIVE OF CHAIRMAN
prof. MUDr. Juraj Payer, CSc., FRCP

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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2. Summary - concise content summary in the extent maximum 10 lines (only at overview papers, case studies and Appendices - General Medicine). Write in 1st or 3rd person singular or plural (unify according the type of an article).

3. Key words - in the extent of 3-6 (only for overview papers and Appendices - General Medicine). 4. English translation: paper title, summary, key words (only at overview papers, and Appendices - General Medicine)

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Examples of citations:
1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor


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Due to practical focus of the journal we would like to ask you to write the paper comprehensively, with emphasis on practical use of provided information in out-
patient internists and general practitioners.


Send contributions in the e-mail to the address: stachova@amedi.sk
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné