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Časopis Internal medicine – Článok Metomorfin effect depending on genetic background in patients with diabetes mellitus type 2

Internal medicine

Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné
Téma: Clinical pharmacology

Metomorfin effect depending on genetic background in patients with diabetes mellitus type 2

Mária Fabianová, Martin Javorský, Lucia Klimčáková, Zbynek Schroner, Eva Babjaková, Pavol Pobeha, Ivan Tkáč

Metformin is according to the international guidelines a first line treatment in type 2 diabetes mellitus. The interindividual variability of treatment effect is not negligible and it could be caused by pharmacogenetics and pharmacokinetics affected bygene polymorphism. The most studied topic among the genetic factors is the role of single nucleotide polymorphism (SNP) on the therapeutic effect of metformin. In this paper we focus on a literature review on effects of gene polymorphism, which affect the pharmacokinetics and pharmadynamics of metformin and thus glycaemic compensation. Only a small number of studies were published on this topic and their results are often contradictory. In genes which affect pharmacokinetics of metformin were found associations of SNP SLC22A1, SLC22A2 and SLC47A1 with effect of metformin on glycaemic compensation. In the future the results of pharmacogenetic studies could contribute to a personalized therapy of patients with type 2 diabetes mellitus dependent on their genotype.

diabates mellitus type 2, metformin, single nucleotid polymorphisms, pharmacokinetic, pharmacodynamic
Interná med. 2012; 12 (9): 455-458

Ročník 2012  Témy časopisu Internal medicine 9 / 2012

Overview works

Margita Belicová
Mária Szántová
Andrej Dukát, Peter Gavorník, Lucia Mistríková, Dávid Baláž, Ján Gajdošík, Ľudovít Gašpar
Eva Bojdová

Clinical pharmacology

Mária Fabianová, Martin Javorský, Lucia Klimčáková, Zbynek Schroner, Eva Babjaková, Pavol Pobeha, Ivan Tkáč
Eva Babjaková, Martin Javorský, Lucia Klimčáková, Mária Fabianová, Pavol Pobeha, Ivan Tkáč
Ján Rajec, Jana Obertová, Beata Mladosievičová
Nie sú dostupné žiadne voľne dostupné články
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REPRESENTATIVE OF CHAIRMAN
prof. MUDr. Juraj Payer, CSc., FRCP

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor


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Due to practical focus of the journal we would like to ask you to write the paper comprehensively, with emphasis on practical use of provided information in out-
patient internists and general practitioners.


Send contributions in the e-mail to the address: stachova@amedi.sk
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné