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Časopis Internal medicine – Článok Pharmacogenetics of insulin secretagogues

Internal medicine

Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné
Téma: Clinical pharmacology

Pharmacogenetics of insulin secretagogues

Eva Babjaková, Martin Javorský, Lucia Klimčáková, Mária Fabianová, Pavol Pobeha, Ivan Tkáč

Sulphonylurea (SU) derivatives and glinines (meglitinides) we rate among oral insulin secretagogues, because they stimulate insulin secretion from pancreatic β-cells. The condition for their effect is preserved residual secretion of pancreatic β-cells. They have been already used in the treatment of diabetes mellitus 2 type (DM2) for more than over 50 years. Despite their overall effectiveness there were observed substantial interindividual differences in the treatment response, disposition of the drug in the organism and also in the frequency of adverse effects. Besides phenotypical differences which cause the stated variability, also different genetic background of patients contribute to it. The knowledge of pharmacogenetics is used in investigation of this variability component. Pharmacogenetics deals with the study of dependency between the treatment response of the patient to the administered drug and his genetic information. The association of genetic polymorphines of enzymes metobolising the derivatives of sulphonylurea (cytochrome-P450 isoenzyme 2C9 coded by the gene CYP2C9). Recently the research was oriented to variants of genes coding target molecules for particular secretagogues as well as candidate genes DM2. Until now the associations of therapeutic effect of insulin secretagogues with polymorphisms of the gene coding transcription factor 7 similar to the factor 2 (TCF7L2), as well as genes coding proteins creating ATP-dependent kalium channel Kir6.2 - (gene KCNJ11) and sulphonylurea receptor 1 (SUR1 - gene ABCC8) were found from these genes.

sulphonylurea, pharmacogenetics, genetic polymorphisms, CYP2C9, TCF7L2, KCNJ11, diabetes type2
Interná med. 2012; 12 (9): 459-463

Ročník 2012  Témy časopisu Internal medicine 9 / 2012

Overview works

Margita Belicová
Mária Szántová
Andrej Dukát, Peter Gavorník, Lucia Mistríková, Dávid Baláž, Ján Gajdošík, Ľudovít Gašpar
Eva Bojdová

Clinical pharmacology

Mária Fabianová, Martin Javorský, Lucia Klimčáková, Zbynek Schroner, Eva Babjaková, Pavol Pobeha, Ivan Tkáč
Eva Babjaková, Martin Javorský, Lucia Klimčáková, Mária Fabianová, Pavol Pobeha, Ivan Tkáč
Ján Rajec, Jana Obertová, Beata Mladosievičová
Nie sú dostupné žiadne voľne dostupné články
CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
prof. MUDr. Juraj Payer, CSc., FRCP

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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Eva Stachová
e-mail: stachova@amedi.sk 

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OVERVIEW PAPERS
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Write the paper on computer in any common text editor.
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- distinguish precisely numbers 1, 0 and letters l, O
- use always parentheses ( )
- explain abbreviations always when first used


MANUSCRIPT REQUIREMENTS

1. An accurate paper title, names and surnames of all authors including titles, authors` workplace. The first author address including the phone number, fax and e-mail address.

2. Summary - concise content summary in the extent maximum 10 lines (only at overview papers, case studies and Appendices - General Medicine). Write in 1st or 3rd person singular or plural (unify according the type of an article).

3. Key words - in the extent of 3-6 (only for overview papers and Appendices - General Medicine). 4. English translation: paper title, summary, key words (only at overview papers, and Appendices - General Medicine)

5. Text
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6. Bibliography
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Examples of citations:
1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

Do not use dots after first names in citations. Do not use colon but dot after names of authors. Use semi-colon after the year of publishing, colon is before pages. If an author is one, two or three - it is necessary to state all. If there are more than three authors it is necessary to write first three and "et all", in Slovak and Czech citations "a spol.".

Due to publishing of autodidactic tests it is necessary to add 4 questions to your article and 4 answers with marking of one correct answer, e.g.: Which of following factors is not related to rosacea?
a. genetic predisposition
b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor


The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are double reviewed.

All published papers are paid.

Due to practical focus of the journal we would like to ask you to write the paper comprehensively, with emphasis on practical use of provided information in out-
patient internists and general practitioners.


Send contributions in the e-mail to the address: stachova@amedi.sk
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné