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Časopis Internal medicine – Článok New possibilities of antiplatelet therapy for acute coronary syndromes

Internal medicine

Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné
Téma: Clinical pharmacology

New possibilities of antiplatelet therapy for acute coronary syndromes

Vasiľ Hricák

„Nothing is clearest over and about that what we found out yesterday , nothing is harder to foresee as that what we will find out tomorrow“(Charles Seward) Background: Antiplatelet therapy is inevitable in the frame of management of acute coronary syndromes (ACS) whether in conservative or interventional and surgical strategies of ACS. Present antiplatelet therapy with clopidogrel + aspirin distinctively contributed to improvement of the treatment for patients with ACS, but despite such treatment thrombotic events persist in earlier or later horizon. Aim: Briefly to approach and summarise essential knowledge on new antiplatelet therapy with prasugrel and ticagrelor in patients with acute coronary syndrome with or without elevation of ST segment in ECG scan (STEMI, NSTEMI and NAP - instable angina pectoris). Conclusion: New antiplatelet drugs are an important contribution in treatment of ACS. Prasugrel with exceptionally prompt onset of effect, and important effectiveness already in first days, has an optimal position in the frame of STEMI, unless contradictions are present. Prasugrel, due to its safety and dominant benefit in diabetics treated with PKI, has to be the drug of choice. Ticagrelor is, by its mechanism of effectiveness and results in treatment of patients with ACS, a breakthrough drug which belongs to everyday antiplatelet armamentarium in the frame of ACS. A distinct profit from treatment with ticagrelor versus other modern antiplatelet treatment is visible in patients with ACS at the age ≥ 75, weight ≤ 60 kg, creatinine clearance ≤ 60 ml/min, who are after TIA, or after ischemic stroke, are sensitive to thienopyridines, even patients already treated with clopidogrel, patients without knowledge of coronary anatomy. Prasugrel and also ticagrelor are administered together with aspirin if there are not absolute contraindications and as soon as possible in patients with ACS. In patients with ACS, if due to any reasons it is not possible to administer ticagrelor or prasugrel, clopidogrel is still indicated.

acute coronary syndrome, antiplatelet therapy, prasugrel, ticagrelor
Interná med. 2013; 13 (3): 143-149

Ročník 2013  Témy časopisu Internal medicine 3 / 2013

Overview works

Barbara Grandtnerová
Miroslav Mydlík, Katarína Derzsiová
Peter Solík, Peter Lesný, Milan Luknár, Ivan Varga, Eva Goncalvesová

Original Works

Peter Bobčák

Clinical pharmacology

Vasiľ Hricák
Juraj Hromec

Case Studies

Jozef Hajdák
Nie sú dostupné žiadne voľne dostupné články
CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
prof. MUDr. Juraj Payer, CSc., FRCP

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

EDITOR-IN-CHIEF
Eva Stachová
e-mail: stachova@amedi.sk 

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SECTIONS

OVERVIEW PAPERS
The latest knowledge on disease and disease groups aetiology, pathogenesis, diagnoses and therapy. Maximum size is 7 pages (font size 12, line spacing 1.5) with maximum six pictures (graphs). In case of more extensive theme it is possible to divide the paper to several parts after agreement with editorial office. Write the article with emphasis on its practical usage for out-patient internists and general practitionrs.

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Write the paper on computer in any common text editor.
write full length of lines (do not use ENTER at the end of a line)
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- distinguish precisely numbers 1, 0 and letters l, O
- use always parentheses ( )
- explain abbreviations always when first used


MANUSCRIPT REQUIREMENTS

1. An accurate paper title, names and surnames of all authors including titles, authors` workplace. The first author address including the phone number, fax and e-mail address.

2. Summary - concise content summary in the extent maximum 10 lines (only at overview papers, case studies and Appendices - General Medicine). Write in 1st or 3rd person singular or plural (unify according the type of an article).

3. Key words - in the extent of 3-6 (only for overview papers and Appendices - General Medicine). 4. English translation: paper title, summary, key words (only at overview papers, and Appendices - General Medicine)

5. Text
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6. Bibliography
Citations are numbered chronologically in bold, references in the text are stated by the number of citations in parentheses. Use maximum 20 citations.

Examples of citations:
1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

Do not use dots after first names in citations. Do not use colon but dot after names of authors. Use semi-colon after the year of publishing, colon is before pages. If an author is one, two or three - it is necessary to state all. If there are more than three authors it is necessary to write first three and "et all", in Slovak and Czech citations "a spol.".

Due to publishing of autodidactic tests it is necessary to add 4 questions to your article and 4 answers with marking of one correct answer, e.g.: Which of following factors is not related to rosacea?
a. genetic predisposition
b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor


The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are double reviewed.

All published papers are paid.

Due to practical focus of the journal we would like to ask you to write the paper comprehensively, with emphasis on practical use of provided information in out-
patient internists and general practitioners.


Send contributions in the e-mail to the address: stachova@amedi.sk
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné