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Časopis Internal medicine – Článok The first experience with glp-1 treatment with analogue liraglutide in diabetologic practice in out-patient practice

Internal medicine

Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné
Téma: 

The first experience with glp-1 treatment with analogue liraglutide in diabetologic practice in out-patient practice

Juraj Vozár, Miriam Avramovová, Viera Doničová, Adriana Ilavská, Peter Jackuliak, Ingrid Jurkovičová, Boris Krahulec, Lujza Štrbová, Eva Tošerová, Martina Chlebcová

In the retrospective analysis we analysed 77 patients with type 2 diabetes mellitus treated with liraglutide in median 12 (min. 6 - max. 24) months. The patients were treated with oral antidiabetic mono, bi- or tritherapy. The age median was 55.5 years and duration of diabetes was 7.7 years. We recorded statistically high significant decrease of fasting blood glucose from 9.3 mmol/l (8.9 - 10) and HbA1c from 8.6 % (8.2 - 8.7) at the beginning of the study to 7.6 mmol/l (6,5 - 8,3) resp. 7.6 % (7.4 - 7.9) % after 12- month follow up (p < 0.001). Similarly, we recorded statistically high significant decrease of weight and body mass index from 102 kg (99 - 112) kg resp. 35.4 kg/m2 (33.7 - 36.3) basal to 98 kg (93 - 103) resp. 33.8 kg/m2 (32,1 - 35,9) after 12- month of treatment (p < 0.001). Lipid parameters were improved at the end of follow up but statistically not significantly. Blood pressure did not change during the 12 months of follow up. The median dose of liraglutide was 1.2 mg/day (1 - 1.5) after 12 months. The incidence of gastrointestinal adverse events occurred temporarily in 15 (20 %) patients and three of them finished the treatment due to that reason. Hypoglycaemia appeared in one patient and disappeared after sulfonylurea secession. Four patients (5 %) finished their treatment due to the high drug supplementary charge. Eleven (14.3 %) patients finished their treatment due to insufficient efficacy on HbA1c levels. The treatment with liraglutide continued successfully in 57 of 77 patients (74 %).

diabetes type 2, liraglutide
Interná med. 2013; 13 (4): 217-222

Ročník 2013  Témy časopisu Internal medicine 4 / 2013

Overview works

Peter Ponťuch
Miriam Kozárová, Mária Rašiová, Robert Magyar, Eva Szabóová, Rastislav Morochovič, Eva Feketeová, Zuzana Gdovinová
Ján Podoba, Ivan Brychta
Gombošová Laura
Petr Smejkal

Ľubomíra Fábryová, Pavol Tisoň
Juraj Vozár, Miriam Avramovová, Viera Doničová, Adriana Ilavská, Peter Jackuliak, Ingrid Jurkovičová, Boris Krahulec, Lujza Štrbová, Eva Tošerová, Martina Chlebcová

Emil Ginter, Igo Kajaba, Marián Šauša

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3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné