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Časopis Internal medicine – Článok Efficacy of aliskiren and hydrochlorothiazide fixed dose combination under real life clinical practice conditions ‒ estrella study

Internal medicine

Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné
Téma: 

Efficacy of aliskiren and hydrochlorothiazide fixed dose combination under real life clinical practice conditions ‒ estrella study

Rudolf Uhliar, Pavol Tisoň

The aim of the presented study was to document the long-term efficacy and safety of aliskiren and hydrochlorothiazide fixed dose combination in a year follow up under real life clinical practice conditions in 1137 patients with insufficient response to previous antihypertensive therapy. Average systolic (sBP) and diastolic (dBP) blood pressure at baseline was 163.1 ± 16.7 mmHg /96.0 ± 10.0 mmHg. After 12 months the average blood pressure was significantly decreased to 133.4 ± 11.9 mmHg/ 80.3 ± 7.0 mmHg (p < 0.001). Blood pressure decreased more in diabetic patients than in patients without diabetes mellitus, however the difference did not reach statistical significance (31.2 mmHg vs 29.4 mmHg) for sBP (p = 0,07) and (16.3 vs 15.2 mmHg) for dBP (p=0.054). There were no significant changes from the baseline during 12 month follow up in serum kalium levels (4.33 ± 0.41 vs 4.42 ± 0.45) (p = 0.09) and serum creatinine levels (86.5 ± 19.2 vs 85.6 ± 18.2 umol/l) (p = 0.11) respectively. In the subgroup of diabetic patients the baseline glomerular filtration rate was significantly lower than in group without diabetes mellitus (69.24 ± 6.22 vs 73.16 ± 7.1 ml/min) (p = 0.001). There was a significant improvement in glomerular filtration vs. baseline (71.65 ± 6.8 ml/min) in diabetes patients at the end of the study (p = 0.01). In the group without diabetes there were no significant changes in glomerular filtration rate. Our study confirmed the long-term efficacy of fixed dose combination of aliskiren with hydrochlorothiazide in patients with insufficient response to previous antihypertensive therapy under real life clinical practice conditions. We have not documented any negative influence of evaluated therapy either on renal functions in overall patient set or in patients with diabetes mellitus.

arterial hypertension, cardiovascular risk, aliskiren, hydrochlorothiazide
Interná med. 2013; 13 (11): 502-506

Ročník 2013  Témy časopisu Internal medicine 11 / 2013

Overview works

Anton Vavrečka, Michelle Swekla
Daniela Kantárová, Milan Buc, Dana Prídavková, Ivana Ságová, Mojmír Vrlík, Marián Mokáň
Branislav Trnavec, Erika Vodrážková
Mária Rašiová, Miriam Kozárová
Peter Gavorník

Rudolf Uhliar, Pavol Tisoň
Nie sú dostupné žiadne voľne dostupné články
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3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
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Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné