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Časopis Internal medicine – Článok Manifestations of subclinical atherosclerosis in patients with obstructive sleep apnea

Internal medicine

Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné
Téma: Original Works

Manifestations of subclinical atherosclerosis in patients with obstructive sleep apnea

Ivana Tomečková1, Pavol Pobeha1, Miriam Kozárová2, Mária Rašiová2, Ivana Paraničová1, Pavol Joppa1, Ružena Tkáčová1

Obstructive sleep apnoea (OSA) is characterized by repeated episodes of total or partial upper airway occlusion during sleep resulting in apnoeic or hypopnoeic episodes. Atherosclerosis, arterial hypertension and metabolic syndrome are the most prevalent comorbidities in OSA patients. Repetitive cycles of hypoxaemia and reoxygenation are accompanied by increased sympathetic activity, oxidative stress, activation of the renin-angiotensin-aldosterone system that contribute to endothelial dysfunction and atherosclerosis. These mechanisms lead to increased cardiovascular morbidity and mortality in patients with OSA. The aim of our study was to investigate relationships between OSA severity and carotid intima-media thickness and parameters of endothelial function. We enrolled 77 subjects who underwent complex overnight polysomnography, carotid ultrasound, and assessment of endothelial function by peripheral arterial tonometry (PAT) and pulse wave velocity (PWV). Based on apnoea-hypopnoea index, subjects were divided into 3 groups: control group – no OSA (n = 10), patients with mild or moderate OSA (n = 34) and patients with severe OSA (n = 33). Intima-media thickness of both the right and left common carotid artery, and their mean value increased from the control group to mild-moderate OSA and to severe OSA (p = 0.045, p = 0.033, p = 0.023, respectively). Post hoc analyses confirmed significantly higher parameters of intima-media thickness in patients with severe OSA compared to subjects with no OSA (p < 0.05 for all comparisons). Assessment of PAT or PWV did not identify significant differences between the study groups. In agreement with literary data our results suggest that OSA contributes to subclinical atherosclerosis.

obstructive sleep apnoea, atherosclerosis, intima-media thickness
Interná med. 2014; 14 (10): 396-401

Ročník 2014  Témy časopisu Internal medicine 10 / 2014

Overview works

Ján Kmec
Viera Spustová, Ingrid Lajdová

Original Works

Ivana Tomečková1, Pavol Pobeha1, Miriam Kozárová2, Mária Rašiová2, Ivana Paraničová1, Pavol Joppa1, Ružena Tkáčová1

Case Studies

Igor Šturdík, Anna Krajčovičová, Jozef Tóth, Miroslav Malík, Vladimír Javorka, Marek Čambal, Zuzana Zelinková

Clinical pharmacology

Ľubomíra Fábryová
Nie sú dostupné žiadne voľne dostupné články
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prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
prof. MUDr. Juraj Payer, CSc., FRCP

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
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prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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c. propionibacterium acnes
d. endothelial growth factor


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Send contributions in the e-mail to the address: stachova@amedi.sk
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné