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Časopis Internal medicine – Článok Monoclonal antibodies against pcsk9 – new hope for patients with high cardiovascular risk

Internal medicine

Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné
Téma: Clinical pharmacology

Monoclonal antibodies against pcsk9 – new hope for patients with high cardiovascular risk

Ľubomíra Fábryová

First-line therapy in secondary prevention and also in primary prevention are statins with wide range of evidence. The current standards for the prevention of cardio-cerebrovascular diseases emphasize the importance of achieving target levels for LDL--cholesterol. Despite everything statins in clinical practice can not meet all the goals. It is therefore no wonder that in the lipid-lowering agents still evolve new medication. The latest promise for high-risk patients (with high or very high cardiovascular risk, with homozygous or heterozygous familial hypercholesterolaemia, intolerant of statins or higher doses of statins) are human monoclonal antibodies against PCSK 9 (proprotein convertase subtilisin/kexin type 9). The results of clinical trials from large-scale programs are groundbreaking. Their importance is comparable to the results of 4S study with simvastatin, which was the first in 1994 demonstrated the benefit of statins in secondary prevention. Despite all this enthusiasm, however, we have to wait for the results of long-term cardiovascular endopoints studies (FOURIER, ODYSSEY-Outcomes and SPIRE), which should be available in late 2017 and early 2018 respectively.

PCSK9, monoclonal antitibodies, evolocumab, alirocumab, bococizumab, PROFICIO, ODYSSEY, SPIRE
Interná med. 2014; 14 (10): 408-416

Ročník 2014  Témy časopisu Internal medicine 10 / 2014

Overview works

Ján Kmec
Viera Spustová, Ingrid Lajdová

Original Works

Ivana Tomečková1, Pavol Pobeha1, Miriam Kozárová2, Mária Rašiová2, Ivana Paraničová1, Pavol Joppa1, Ružena Tkáčová1

Case Studies

Igor Šturdík, Anna Krajčovičová, Jozef Tóth, Miroslav Malík, Vladimír Javorka, Marek Čambal, Zuzana Zelinková

Clinical pharmacology

Ľubomíra Fábryová
Nie sú dostupné žiadne voľne dostupné články
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REPRESENTATIVE OF CHAIRMAN
prof. MUDr. Juraj Payer, CSc., FRCP

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
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doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
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prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
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prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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c. propionibacterium acnes
d. endothelial growth factor


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patient internists and general practitioners.


Send contributions in the e-mail to the address: stachova@amedi.sk
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné