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Časopis Internal medicine – Článok The genetic variant for key enzyme of gluconeogenesis PEPCK/PCK1 and metformin efficacy in patients with diabetes mellitus type 2: pharmacogenetic study

Internal medicine

Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné
Téma: OVERVIEW WORKS

The genetic variant for key enzyme of gluconeogenesis PEPCK/PCK1 and metformin efficacy in patients with diabetes mellitus type 2: pharmacogenetic study

Igor Gaľa, Lucia Klimčáková, Mária Štolfová, Ivana Gotthardová, Eva Babjaková, Zbynek Schroner, Ivan Tkáč, Martin Javorský

Pharmacogenetic studies examine effects of gene variants on drug efficacy and side effects. The aim of this study was
to investigate possible association of the gene variant encoding key enzyme of gluconeogenesis – PEPCK (phosphoenolpyruvate
carboxykinase) encoded by PCK1 with response to metformin in type 2 diabetes patients. The study included
148 drug-naive patients with type 2 diabetes. PCK1 rs4810083 polymorphism was determined by PCR followed by
melting curve analysis. PCK1 rs4810083 was significantly associated with the reduction in HbA1c after 6-month treatment.
The CC homozygotes experienced by 0.43 % larger reduction in glycated haemoglobin compared with the carriers
of T allele (CC: 0.98 ± 0.16 vs. CT+TT: 0.55 ± 0.09 %; p = 0.029). In the multivariate logistic regression CC homozygotes
had a significantly higher chance of achieving therapeutic goal (HbA1c < 6.5 %): odds ratio (OR) 3.33 (95 % CI:
1.32 – 8.39; p = 0.011). If replicated the results of this study may find future practical implication in personalised treatment
of type 2 diabetes.

pharmacogenetics, gluconeogenesis, gene variant, metformin, diabetes
Interná med. ; 15 (5): 228-230

Ročník 2015  Témy časopisu Internal medicine 5 / 2015

OVERVIEW WORKS

Viera Fábryová, Peter Božek, Monika Drakulová, Andrea Kollárová, Zuzana Laluhová-Striežencová, Michaela Macichová, Jana Netriová
Mária Rašiová, Ľubomír Špak, Ľudmila Farkašová
Marek Rác, Tomáš Koller, Ľubomír Skladaný, Martin Janíčko, Peter Jarčuška
Ján Staško, Miroslava Dobrotová, Jela Ivanková, Lucia Stančiaková, Zuzana Jedináková, Juraj Sokol, Ingrid Škorňová, Ľubica Kořínková, Peter Kubisz
Igor Gaľa, Lucia Klimčáková, Mária Štolfová, Ivana Gotthardová, Eva Babjaková, Zbynek Schroner, Ivan Tkáč, Martin Javorský
Mária Černá
Andrej Dukát, Ján Gajdošík, Milan Kriška, Fedor Šimko, Peter Gavorník, Ľudovít Gašpar

CASE STUDIES

Ivica Lazúrová, Peter Jarčuška, Ľubomír Skladaný, František Hampl
Nie sú dostupné žiadne voľne dostupné články
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REPRESENTATIVE OF CHAIRMAN
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MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
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prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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2. Summary - concise content summary in the extent maximum 10 lines (only at overview papers, case studies and Appendices - General Medicine). Write in 1st or 3rd person singular or plural (unify according the type of an article).

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Examples of citations:
1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor


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Due to practical focus of the journal we would like to ask you to write the paper comprehensively, with emphasis on practical use of provided information in out-
patient internists and general practitioners.


Send contributions in the e-mail to the address: stachova@amedi.sk
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné