Mária Szántová, Michaela Fedelešová, Zuzana Ďurkovičová
Recent 20 years have brought many large population studies and meta-analyses about the relation between coffee consumption
and hepatic disease manifestations. Consensually they detected an inversion dose-dependent correlation
between coffee consumption and non-alcoholic steatohepatitis (NASH), alcoholic cirrhosis, hepatocellular carcinoma
(HCC) and mortality related to these diseases. The paper in a summary form provides results from until now published
studies and meta-analyses, and we assume mechanisms of hepatoprotective coffee effect. Coffee hepatoprotection involves
antioxidative, antifibrotic, anticancerous effects and effects of insulin sensitivity. The majority of mechanisms
are mediated through modulation of gene expression of key enzymes of fatty acid synthesis, mRNA modulation involved
in autophagic process, reduction of endoplasmic reticulum reduction, subsequent anti-inflammatory cytokines
and fibrogenesis. Caffeine, diterpenes (cafestol and kahweol), chlorogenic acids, polyphenols and melanoidins are responsible
for protective coffee effects