Ivana Ságová, Matej Stančík, Anton Vaňuga, Dušan Pavai, Helena Urbánková, Peter Vaňuga, Anton Lacko
Endothelins are peptide hormones with a potent vasoconstrictor activity. The most important is endothelin 1, which
causes constriction of the coronary, renal, pulmonary and cerebral arteries. It inhibits the secretion of vasopressin and
atrial natriuretic factor. Endothelin is important because of its effect in the pathogenesis of cardiovascular disease, as
well as in the pathogenesis of bronchial asthma, Reynaud’s syndrome, renal vascular disease, and stroke. The aim of
this study was to verify plasmatic level of endothelin in patients with diabetes mellitus type 1. We observed higher level
of endothelin in patients with DM type 1 compared to the controls. Endothelin levels in patients with type 1 diabetes
without chronic complications correlated with impaired microcirculation in the dermis, while in type 1 diabetics
with chronic complications, it correlated with