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Časopis Internal medicine – Článok The relationship of selected gene variants to manifestations of subclinical atherosclerosis in peripheral arteries in type 2 diabetics

Internal medicine

Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné
Téma: Original works

The relationship of selected gene variants to manifestations of subclinical atherosclerosis in peripheral arteries in type 2 diabetics

Zuzana Malachovská, Miriam Kozárová, Martin Javorský, Ivan Tkáč

Introduction: Endothelial dysfunction (ED) is characterized as functional, reversible damage to endothelial cells resulting
from oxidative stress and changes in the bioavailability of nitric oxide. ED is an intermediate stage in the development
of atherosclerosis.
Aim: The aim of the study was to find out in the Slovak population the frequency of alleles and genotypes of selected gene
polymorphisms associated with the manifestations of subclinical atherosclerosis in peripheral arteries in the risky population
of type 2 diabetics.
Methods: Genetic association study included 124 asymptomatic type 2 diabetics of average age of 62,9 ± 9,1 years.
Each of the patients went through a complex vascular protocol aimed at detecting of subclinical atherosclerosis in the
peripheral arteries, specifically pulse wave velocity (PWV) measurement, intima-media thickness (IMT) and flow-mediated
dilation (FMD). The DAB2IP rs7025486, PAX2 rs6584389 and Hp rs72294371 gene polymorphisms were tested.
Results: The DAB2IP rs7025486, PAX2 rs6584389 and Hp rs72294371 polymorphisms were significantly associated with
intima-media thickness (IMT average and IMT of the left side). In multivariate linear regression analysis with mean IMT
as a dependent variable, among the genetic factors, the C allele of polymorphism PAX2 rs6584389 was a significant IMT
thickness predictor (β = 0,0460; p = 0,029). From the other genetic factors, the strongest predictors were: asymmetric
dimethylarginine (ADMA) (β=0,200; p = 0,022), glycated hemoglobin (HbA1c) (β = 0,0237; p = 0,003), male gender
(β = 0,0952, p = 0,011) and age (β = 0,00953; p < 0,001).
Conclusion: Due to the independence from traditional risk factors of atherosclerosis, detected gene polymorphisms,
DAB2IP rs7025486, PAX2 rs6584389 and Hp rs72294371, may point to new mechanisms of atherogenesis with potential
direct implication for practice in terms of individualization of therapy in carriers of these polymorphisms.

gene polymorphism, endothelial dysfunction, type 2 diabetes mellitus, pulse wave velocity, intima-media thickness, flow-mediated dilation
Interná med. 2017; 17 (7-8): 317-321

Ročník 2017  Témy časopisu Internal medicine 7 / 2017

Overview works

Ivana Valočiková
Marta Karhanová, Jana Kalitová
Emil Martinka, Ivan Tkáč, Peter Galajda, Marián Mokáň
Mária Sarvašová, Alena Koščálová, Igor Stankovič, Sena Starý
Iveta Kurčová

Original works

Petra Senajová, Ivana Trojová, Zuzana Štrbová, Radovan Tiško, Ružena Tkáčová, Pavol Joppa
Zuzana Malachovská, Miriam Kozárová, Martin Javorský, Ivan Tkáč
Nie sú dostupné žiadne voľne dostupné články
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Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné