Ivana Trojová, Miriam Kozárová, Zuzana Malachovská, Darina Petrášová, Ivana Paraničová, Ružena Tkáčová, Pavol Joppa
Obstructive sleep apnoea (OSA) is associated with increased arterial stiffness and endothelial dysfunction. OSA-related
oxidative stress and systemic inflammation may play a role in vascular impairment. The aim of our interventional
study was to investigate effects of continuous positive airway pressure (CPAP) therapy on arterial stiffness, oxidative
stress and body composition in patients with moderate and severe OSA. In patients compliant with CPAP therapy, reductions
of pulse wave velocity in association with reductions in serum oxidized low-density lipoprotein (oxLDL) were
observed after 3 months. Improvements in arterial stiffness were observed regardless the body weight or body composition
change. Our results suggest that in patients with OSA but without overt cardiovascular diseases, good compliance
to CPAP may improve arterial stiffness in association with reductions in oxidative stress.