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Časopis Internal medicine – Článok The association between abdominal aortic diameter and serum collagen XVIII levels

Internal medicine

Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné
Téma: ORIGINAL WORKS

The association between abdominal aortic diameter and serum collagen XVIII levels

Mária Rašiová, Ľudmila Farkašová, Darina Petrášová, Martin Koščo, Matej Moščovič, Zuzana Tormová, Lenka Kačureková

Background: The identification of abdominal aortic aneurysm (AAA) biomarker offers a perspective to evaluate disease progress and rupture risk. The goal of our study was to determine the association between selected serum biomarkers and abdominal aortic diameter.
Patients and methods: One hundred and two patients (88 men and 14 women; mean age 70.0 ± 8.7 years) were included in a single center cross-sectional study conducted between February, 2016 and October, 2018. Study sample consisted of 57 patients with nonruptured infrarenal AAA and 45 control patients. AAA was defined as subrenal dilatation of abdominal aorta ≥ 3 cm. Concentrations of serum biomarkers (collagen IV, collagen XVIII, insulin-like growth factor-1, peroxiredoxin-1) were measured by an enzyme-linked immunosorbent assay (ELISA). Adjustments including age, arterial hypertension, coronary artery disease, sex, active smoking, LDL-cholesterol, statin treatment, diabetes mellitus and fibrinogen were performed in multivariate models.
Results: Higher collagen XVIII was found in AAA patients in comparison with the control patients (39.5 vs 25.0 ng/ml; p = 0.002). Diameter of abdominal aorta was positively associated with collagen XVIII in univariate (B = 0.14; p = 0.013), and in multivariate analysis (B = 0.15; p = 0.029), i.e. increase in collagen XVIII by 1 ng/ml corresponded to an increase in abdominal aortic diameter by 0.15 mm. Patients with serum collagen XVIII in the third tertile (˃ 47 ng/ml) had 4.23–times higher risk of AAA compared to patients with collagen XVIII in the first and second tertiles (OR 4.23; 95% CI 1.42 – 11.6; p = 0.020). No association was found between other examined biomarkers and abdominal aortic diameter.
Conclusion: Abdominal aortic diameter was positively associated with serum collagen XVIII level.

abdominal aortic neurysm, biomarker, collagen XVIII
Interná med. 2019; 19 (11): 417-422

Ročník 2019  Témy časopisu Internal medicine 11 / 2019

OVERVIEW WORKS

Ivica Lazúrová
Zuzana Kovaničová, Barbara Ukropcová, Jozef Ukropec
Ľudmila Trejbalová
Beáta Bolerázska, Anna Birková, Beáta Čižmárová, Beáta Hubková
Ivana Jochmanová

ORIGINAL WORKS

Mária Rašiová, Ľudmila Farkašová, Darina Petrášová, Martin Koščo, Matej Moščovič, Zuzana Tormová, Lenka Kačureková

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3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
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Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné