Téma: Review papers

Thromboembolism in childhood

Kamila Trebuňová, Ladislav Bratský, Marcel Zachar, Jana Chudová

The occurrence of thromboembolism during childhood has increasing significant mortality and morbidity. There is direct connection with invasive diagnostic and therapeutic measures and intensive care. The congenital thrombophilic disorders are one of the main etiologic factors of thrombosis in children. The aim of our study was to elucidate the aetiology of thromboembolism in our group of patients with congenital and acquired thrombophilic disorders and to show the results of therapy. The group consists of 14 patients, the age from 1 month to 17 years. Four of our children have confirmed diagnosis of congenital thrombophilic disorder. Two patients has confirmed mutation of FV-Leiden. The other acquired aetiology of thromboembolism was infection (four times), central venous line, (two times), malignancy (2 times), trauma (two times), pregnancy, with vascular anomaly (1x), and hormonal contraceptives. The early initial therapy with heparin and warfarin was successful in cases of venous thromboses of central nervous systems.
Keywords: thromboembolism in childhood, „thrombophilic families“, risk factors, brain venous thrombosis

Ročník 2007  Témy časopisu Paediatrics 3 / 2007

EDITOR IN CHIEF
prof. Peter Banovcin, MD., Ph.D.: Senior specialist of the Ministry of Health in the Slovak Republic for Pediatrics; Head of Department of Pediatrics, University Hospital Martin, Jessenius Faculty of Medicine of Comenius University in Bratislava; Head of Center of Excellence for Experimental and Clinical Research in Respirology; Martin Slovakia

VICE EDITOR IN CHIEF
assoc. prof. Milos Jesenak, MD., MSc., Ph.D., MBA, Dott.Ric., MHA: Head of Center for diagnosis and treatment of primary immunodeficiencies, Department of Pediatrics, University Hospital Martin, Jessenius Faculty of Medicine of Comenius University in Bratislava; Martin, Slovakia

SCIENTIFIC EDITORS
assoc. prof. Mario Barreto, MD., PhD: Department of Pediatrics, 2nd Faculty of Medicine, University La Sapienza, St. Andrew’s Hospital, Rome; Italy
assoc. prof. Vladimir Bzduch, MD., Ph.D.: Department of Pediatrics, Children Teaching Hospital in Bratislava, Faculty of Medicine of Comenius University Bratislava; Slovakia
dr. n. med. Joachim Buchvald, Ph.D.: Head of Department of Pediatric Pulmonology and Cystic Fibrosis; Rabka-Zdroj, Poland
assoc. prof. Miriam Ciljakova, MD., Ph.D.: Head of Division of Pediatric Endocrinology and Diabetology, Department of Pediatrics, University Hospital Martin, Jessenius Faculty of Medicine of Comenius University in Bratislava; Martin, Slovakia
assoc. prof. Milan Dragula, MD., Ph.D.: Head of Department of Pediatric Surgery, Jessenius Faculty of Medicine of Comenius University in Bratislava, University Hospital Martin; Martin, Slovakia
ass. prof. Peter Durdik, MD., Ph.D.: Head of Division of Pediatric Pulmonology, Department Pediatrics, Jessenius Faculty of Medicine of Comenius University in Bratislava, University Hospital Martin; Martin, Slovakia
assoc. prof. Katarina Furkova, MD., Ph.D.: Head of the Department of Pediatrics, Vice-dean of Faculty of Medicine of Slovak Medical University; Bratislava, Slovakia
prof. dr. med. Janusz Haluszka, MD., Ph.D.: Head of Institute of Public Health, Medical College, Jagellonian University; Krakow, Poland
ass. prof. Zuzana Havlicekova, MD., Ph.D.: Head of Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics of Jessenius Faculty of Medicine of Comenius University in Bratislava; University Hospital Martin; Martin, Slovakia
Marian Hrebik, MD., Ph.D., MPH: Head of Pediatric Cardiology Center, Comenius University in Bratislava; Bratislava, Slovakia
prof. Hana Hrstkova, MD., Ph.D.: Department of Pediatrics, University Teaching Hospital in Brno, University of Masaryk in Brno; Brno, Czech republic
prof. Henrieta Hudeckova, MD., Ph.D.: Senior specialist of the Ministry of Health in the Slovak Republic for Epidemiology, Head of Department of Public Health, Jessenius Faculty of Medicine of Comenius University in Bratislava; Martin, Slovakia
assoc. prof. Lubica Jakusova, MD., Ph.D.: Department of Pediatrics, Jessenius Faculty of Medicine of Comenius University in Bratislava, University Hospital Martin; Martin, Slovakia
assoc. prof. Emilia Kaiserova, MD., Ph.D.: Head of Department of Pediatric Hematology and Oncology, Children Teaching Hospital in Bratislava, Faculty of Medicine of Comenius University Bratislava; Slovakia
assoc. prof. Ludmila Kostalova, MD., Ph.D.: Department of Pediatrics, Children Teaching Hospital in Bratislava, Faculty of Medicine of Comenius University Bratislava; Slovakia
prof. Karol Kralinsky, MD., Ph.D.: Head of Department of Pediatrics, Head of Department of Pediatric Intensive Care, Children Teaching Hospital in Banska Bystrica, Slovak Medical University; Banska Bystrica, Slovakia
prof. Zuzana Kristufkova, MD., Ph.D., MPH: Head of Department of Public Health, Vice-dean of Faculty of Medicine of Slovak Medical University; Bratislava, Slovakia
assoc. prof. Milan Kuchta, MD., Ph.D.: President of Slovak Pediatric Society, Department of Pediatrics, Children Teaching Hospital in Kosice, University of Pavol Jozef Safarik; Kosice, Slovakia
prof. Jozef Masura, MD., Ph.D., FSCAI: Head of Interventional and Diagnostic Pediatric Cardiology, National Institute for Heart and Vascular Diseases, Pediatric Cardiology Center, Comenius University in Bratislava; Bratislava, Slovakia
prof. Vladimír Mihal, MD., Ph.D.: Head of Department of Pediatrics, Faculty Teaching Hospital in Olomouc, University of Palacky; Olomouc, Czech Republic
assoc. prof. Slavomir Nosal, MD., Ph.D.: Head of Department of Pediatric Intensive Care Unit, University Hospital Martin, Jessenius Faculty of Medicine of Comenius University in Bratislava; Martin, Slovakia
prof. MUDr. Petr Pohunek, CSc.: Head of Department of Pediatric Pulmonology, Department of Pediatrics, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czech Republic
Elena Prokopova, MD.: Senior specialist of the Ministry of Health in the Slovak Republic for Pediatric Primary Care, Out-patient clinic for children and adolescent; Bratislava, Slovakia
prof. Roman Prymula, MD., Ph.D.: Department of Epidemiology, University of Defense; Hradec Kralove, Czech Republic
ass. prof. Zuzana Rennerova Bohmerova, MD., Ph.D.: Department of Pediatric Pulmonology, Children Teaching Hospital in Bratislava, Faculty of Medicine of Comenius University in Bratislava; Slovakia
prof. Tibor Sagat, MD., Ph.D.: Department of Pediatric Intensive Care Unit, Children Teaching Hospital in Bratislava, Faculty of Medicine of Comenius University in Bratislava; Bratislava, Slovakia
prof. Miroslav Sasinka, MD., DSc.: Department of Pediatrics, Faculty of Medicine of Slovak Medical University; Bratislava, Slovakia
Marta Spanikova, MD.: President of Slovak Society of Primary Pediatric Care, Out-patient clinic for children and adolescent; Bratislava, Slovakia
assoc. prof. Veronika Vargova, MD., Ph.D.: Department of Pediatrics, Children Teaching Hospital in Kosice, University of Pavol Jozef Safarik; Kosice, Slovakia
prof. Maria Pia Villa, MD., Ph.D.: Head of Department of Pediatrics, 2nd Faculty of Medicine, University La Sapienza, St. Andrew’s Hospital, Rome; Italy
prof. Mirko Zibolen, MD., Ph.D.: Senior specialist of the Ministry of Health in the Slovak Republic for Neonatology; Head of Department of Neonatology, Jessenius Faculty of Medicine of Comenius University in Bratislava, University Hospital Martin; Martin, Slovakia

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Eva Stachová
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Pediatria (Bratislava)
ISSN 1336-863X

INTRUCTIONS FOR AUTHORS

Pediatria (Bratislava) is a bimonthly peer-reviewed scientific journal published in both printed and on-line versions. There are 6 issues per year with irregular supplemental issues (e.g. proceedings from scientific meetings). The journal published reports (Original papers, Review papers, Case reports, Diagnostic and therapeutic algorithms, Letters to Editor, Miscellaneous) on all aspects and areas from paediatrics and related areas of the medicine. The journal applies all the necessary procedures ensuring the originality of the manuscripts according to the Universal Requirements for Manuscripts Submitted to the Biomedical Journals, prepared by the International Committee of Medical Journal Editors (ICMJE) and WAME (World Association of Medical Editors).
All the authors and co-authors should significantly contribute to the research and work. Authors have to declare any conflict of interests in relationship with the submitted and later published accepted work. Manuscripts sould be submitted with the understanding that they have neither been published, nor are under consideration for publication elsewhere (except in the form of an abstract). Authors should state this fact in the accompanying Cover letter. Accepted and published manuscripts become the sole property of the Journal and will be copyrighted by A-Medi managements, Ltd. By submitting a paper to the journal, the author(s) agree(s) to each ot the above stated conditions. After the acceptance of the manuscript, author(s) will receive Copyright Agreement Form, which should be signed by all the authors and send back to the journal before the publication of the paper.

GENERAL MANUSCRIPT REQUIREMENTS

Title page:
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Summary:
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Acknowledgements:
• All the collaborators and contributors who do not fulfil the criteria for authorship should be listed in this section.
Language:
• The manuscripts and contributions should be written in Slovak, Czech or English language.
• In case of Slovak and Czech language of the manuscript, the submission should contain English translation of the Title, Summary and Key words in a separate file.
General rules:
• Write the paper on computer in any common text editor.
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• Do not arrange the text into columns - do not do page make-up.
• Distinguish precisely numbers 1, 0 and letters l, O.
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ARTICLES TYPE

REVIEW PAPERS
The review papers are focused on the latest knowledge on disease and disease groups’ etiology, pathogenesis, diagnoses and therapy. Maximum length is 7 pages of text (font Times New Roman, font size 12, line spacing 1.5). Do not arrange the text into columns - do not do page make-up. Figures, graphs and tables should be sent separately. In case of more extensive theme elaboration it is possible to divide the paper to several parts after agreement with editorial office. Write the article with emphasis on its practical usage for paediatricians.

ORIGINAL PAPERS
An original paper brings scientific elaboration of studied issues. It is divided into usual parts together with a structured summary. If it is an original paper, a structured summary with five parts is required:
• Background/Objectives: Briefly (2 - 3 sentences) state the knowledge, or its possible drawbacks, from which authors initially started conceptual framework of their work.
• Material/Subjects: Accurately, in numerical values characterize the examined and control group (age, sex, examined samples, numerical values; patients are not material but subjects)
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• At the end of summary it is necessary to put Key words on a separate line in the extent of 3 - 6 words.
Original paper is divided into standard sections: Introduction, Material/Subjects and Methods, Results and Conclusions.

CASE REPORT STUDIES:
Maximum extent is 5 pages. Structuring: summary, introduction, case study, discussion, conclusions, bibliography. Only case reports bringing and showing some new interesting facts or data could be published.

DIAGNOSTIC AND THERAPEUTICAL ALGORITHMS:
Diagnosis and therapy processed into tables and schemes, with minimum text, with emphasis on conciseness and clarity.

MISCELLANEOUS
Reaction to review papers, published manuscripts, news in the field of diagnostics, therapy, trial results (maximum 3 pages), reports from professional events and congresses, reviews of the recently published books not older than 1 year. Maximum extent is 1 page. Write the title of the paper in Slovak/Czech, authors, affiliation, and then title of the paper in English with full citation.

REFERENCES:

• References are ordered alphabetically according to the surname of the first author.
• References in the text are stated by the number of citations in parentheses.
• Use maximum of 25 citations, especially from last 5 years.
• All authors have to be stated in citations. Do not use the abbreviation "et al".

Examples of citations:
Book:
BRISCOE M.H., CLARK T.J., SIMONCELI G.H., DEVILD P.S. Preparing scientific illustrations? A guide to better posters, presentations and publications. 2nd Ed. New York: Springer-Verlag, 1996, 217 pp.
KOLLMANOVÁ S., BUBENÍKOVÁ L. Atlas medicínskych ilustrácii. 5. vyd. Martin: Osveta, 2001, 205 s.
Book chapter:
OSBORNE B.E. The electrocardiogram of the rat. In: BUDDEN R.,DETWEIERD K., ZBINDEN G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Thorax, 53, 1981, p. 15-27.
Journal articles:
BURNARD, P. Writing for publication: a guide for those who must. Nurse Educ Today, 17, 1999, p. 208-212.
ČERVEŇOVÁ, O., POLÁK, V., VICIANOVÁ, K. Sríning a liečebné postupy anomálii uropoetického systému v novorodeneckom veku. Pediatria (Bratisl.), 48, 1993, s. 233-236.
Web sources:
CARROLL, L. Exploring genes and genetic disorders [online]. Nov. 2004 [cit. 2005-02-10]. Available:[http://www.germany.eu.net/books/alice/html].

PEER-REVIEW PROCESS

Pediatria (Bratislava) is committed to peer-review integrity and ensures the highest standard of review process. After the evaluation of the suitability of the paper for this journal by the Editor, a double-blind peer-review process is initiated. Peer-review process is provided at least by two independent and anonymous expert reviewers according to the standard evaluation criteria. The reviewers are unaware of the identity of the authors, and viceversa, the authors are unaware of the identity of the reviewers. Review manuscripts are treated confidentionally prior their publications. Their recommendations are evaluated by Editors and the final decision (accept as written, accept after minor revision, accept after major revision and elaboration, or reject) is send to the authors. The revision of the paper is expected within two weeks. All the changes should be highlighted in the text (i tis possible to use the tracking tools). The submission of the revised version have to be accompanied by Cover letter with the reactions and responses of the authors point-by-point to the referees‘ reports. All the papers after the acceptance are edited, proof is send to the corresponding author for the final corrections and approval and than all the papers are available on the Journal’s webpage free of charge: http://www.amedi.sk/uvod.html.

PUBLICATION FEES

The papers accepted for publication in Pediatria (Bratisl.) after sucessful peer-review process are published free of charge. The editorial board reserved to make small stylistic changed in the paper.

All the contributions should be sent by e-mail to: stachova@amedi.sk
A confirmation of the manuscript receivement will be send to the corresponding author soonly after the submission.