Miroslav Šašinka, Katarína Furková
Food non-IgE protein induced enterocolitis syndrome (FPIES) is a potentially relevant disorder of hypersensitivity to proteins manifested by complex profuse vomitus, diarrhea and systemic inflammatory reaction that may result in dehydration and hypovolemic shock in 15-20 % of patients. The syndrome arises typically on first and/or second ingestion of milk or soy formula, but it may also arise on ingestion of solid food (such as rice, oats, barley, chicken, eggs, turkey, peanuts). In the pathogenesis of FPIES the main role is played by T-cells, antigen-specific regulation T-cells, excessive secretion of TNF-α, decrease in TGF-β1 and humoral reactions (increase of specific IgA antibodies and decrease of specific IgG4). Other inflammatory cells (neutrophil leucocytes, thrombocytes, eosinophil leucocytes) are also of great importance. The authors analyze etiology, pathogenesis, clinical picture, therapy and syndrome prognosis.