Ľubica Perďochová
Aim of the study: Acute otitis media (AOM) is one of the most common diseases in children age. The most frequent causative is Streptococcus pneumoniae (SP). Effect of vaccination has resulted in changes in the incidence of SP serotypes. This study analyses an actual status. Methods: Serotyping strains SP Quellung reaction using sera from Statens Serum Institut, Copenhagen, Denmark, an examination the sensitivity SP to antibiotics using disk diffusion test and E-test. Results: The present study analyses results from children 0-5 years aged in Bratislava region and districts Galanta, Dunajská Streda, Topoľčany, Komárno, Prešov, Košice, with AOM and positive isolation of SP. On the group 312 children in the period 2008 to 2012 are shown changes in the distribution of serotypes SP in Slovakia due to vaccination. Significant increase of serotypes 19A (from 8,1 % to 52,7 %) and 3 (from 2,7 % to 16,5 %) was observed. SP resistance of penicillin in this study was 8,1 %. Serotypes 19A, 14 and 6B showed the highest resistance to macrolides, clindamycin and co-trimoxazole. Conclusion: The results of the analysis showed the replacement SP serotypes in children after the introduction of vaccination. Monitoring the distribution of serotypes provides the necessary information into the current state and needs to continue. Amoxicillin in increased dosage is suitable for treatment of AOM caused by penicillin non-susceptible strains SP.