Miroslav Šašinka, Katarína Furková, Igo Kajaba
Animal models of chronic kidney disease (CKD) show that acid-inducing dietary protein exacerbates and base-inducing
protein ameliorates nephropathy progression, and that increased intake of acid-inducing but not base-inducing dietary
protein exacerbates progression. Experiments showed show that dietary acid reduction reduces kidney injury and slows
nephropathy progression in patients with CKD and reduced glomerular filtration rate (eGFR). Clinical studies show of
the CKD progression is slowing with acid proteins but no with base Na+ diet. Base-inducing fruits and vegetables reduce
kidney injury in patients with reduced GFR and improve metabolic acidosis in CKD. It´s means that for the CKD progression
is more important a quality of the dietary protein than their quantity. Dietary protein type rather than amount
might more importantly affect nephropathy progression and this is other way for slowing of the CKD progression. Now
days we have only small EBM-controlled studies, we need larger further EBM-studies will determine if CKD patients
should be given base-inducing food as part of their management.