Vladimír Ferianec, Anna Plichtová
Preterm premature rupture of membranes (PPROM) in the pregnancy is one of the most alarming problems in current obstetrics. It greatly contributes to fetal and perinatal morbidity and mortality (intraamniotic infection, pregnancy loss, preterm labor, neonatal pulmonary hypoplasia). Perinatal mortality is about 60 %, one third of which represents intrauterine fetal demise. Surviving neonates suffer from various ophthalmologic, respiratory, and neurological complications. There are multiple different clinical approaches regarding treatment of PPROM. Proactive management schemes include attempts to restore volume of amniotic fluid by instilling normal saline into the amniotic cavity (amnioinfusion) or procedures attempting to reseal the defect in fetal membranes.